Kamangar Farin, Qiao You-Lin, Schiller John T, Dawsey Sanford M, Fears Thomas, Sun Xui-Di, Abnet Christian C, Zhao Ping, Taylor Philip R, Mark Steven D
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Int J Cancer. 2006 Aug 1;119(3):579-84. doi: 10.1002/ijc.21871.
Each year, esophageal and gastric cancers cause more than 900,000 deaths worldwide. Human papilloma virus (HPV), especially type 16, has been suggested to have a role in the etiology of esophageal cancer, however, the results of previous seroepidemiological studies have not been consistent. We conducted a large prospective study to examine the association between serum antibodies to HPV 16, HPV 18 and HPV 73 and subsequent development of esophageal squamous cell carcinoma (ESCC), gastric cardia adenocarcinoma (GCA), and gastric noncardia adenocarcinoma (GNCA) in a high-risk population for these cancers in Linxian, China. Case and control subjects for this study were selected from the 29,584 participants of the Linxian General Population Trial. Prediagnostic serum samples from 99 cases of ESCC, 100 cases of GCA, 70 cases of GNCA, and 381 age- and sex- matched controls were selected for this study. The presence of antibodies to HPV virus-like particles was determined by type-specific enzyme-linked immunosorbent assays. Fewer than 15% of ESCC, GCA, or GNCA cases were positive for each HPV type, and no significant associations were found. The adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for HPV 16 seropositivity and ESCC, GCA, and GNCA risk were 1.6 (0.8-3.3), 1.3 (0.6-2.8) and 0.4 (0.1-1.6), respectively. The comparable ORs (95% CIs) for HPV 18 were 1.0 (0.4-2.2), 0.9 (0.4-2.1) and 1.5 (0.6-3.4). For HPV 73, these figures were 1.3 (0.6-2.5), 1.2 (0.6-2.3) and 0.9 (0.4-2.1). The results of this study do not support a major role for HPV 16, HPV 18 and HPV 73 in the etiology of esophageal and gastric cancers in Linxian, China.
每年，食管癌和胃癌在全球导致超过90万人死亡。人乳头瘤病毒（HPV），尤其是16型，被认为在食管癌的病因学中起作用，然而，先前血清流行病学研究的结果并不一致。我们进行了一项大型前瞻性研究，以检验在中国林县这些癌症的高危人群中，血清中针对HPV 16、HPV 18和HPV 73的抗体与随后发生食管鳞状细胞癌（ESCC）、贲门腺癌（GCA）和非贲门腺癌（GNCA）之间的关联。本研究的病例和对照受试者选自林县普通人群试验的29584名参与者。本研究选取了99例ESCC、100例GCA、70例GNCA患者以及381名年龄和性别匹配的对照者的诊断前血清样本。通过型特异性酶联免疫吸附试验测定HPV病毒样颗粒抗体的存在情况。每种HPV类型在ESCC、GCA或GNCA病例中的阳性率均低于15%，且未发现显著关联。HPV 16血清阳性与ESCC、GCA和GNCA风险的校正比值比（OR）及95%置信区间（95%CI）分别为1.6（0.8 - 3.3）、1.3（0.6 - 2.8）和0.4（0.1 - 1.6）。HPV 18的可比OR（95%CI）分别为1.0（0.4 - 2.2）、0.9（0.4 - 2.1）和1.5（0.6 - 3.4）。对于HPV 73，这些数字分别为1.3（0.6 - 2.5）、1.2（0.6 - 2.3）和0.9（0.4 - 2.1）。本研究结果不支持HPV 16、HPV 18和HPV 73在中国林县食管癌和胃癌病因学中起主要作用。
