Fisher Ohad, Siman-Tov Rama, Ankri Serge
Department of Molecular Microbiology, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O.B. 9649, 31096 Haifa, Israel.
Mol Biochem Parasitol. 2006 May;147(1):48-54. doi: 10.1016/j.molbiopara.2006.01.007. Epub 2006 Feb 9.
The protozoan parasite Entamoeba histolytica expresses a cytosine-5 DNA methyltransferase (Ehmeth) that belongs to the Dnmt2 proteins family. The biological function of members of the Dnmt2 family is unknown. Constitutive overexpression of Ehmeth resulted in a pleiotropic phenotype that includes accumulation of multinucleated cells, upregulation of Heat shock protein 70 (HSP70) expression and resistance to oxidative stress. This pleiotropic phenotype suggests that Ehmeth plays an important role in the control of key cellular processes in the parasite.
原生动物寄生虫溶组织内阿米巴表达一种属于Dnmt2蛋白家族的胞嘧啶-5 DNA甲基转移酶（Ehmeth）。Dnmt2家族成员的生物学功能尚不清楚。Ehmeth的组成型过表达导致多效性表型，包括多核细胞的积累、热休克蛋白70（HSP70）表达上调以及对氧化应激的抗性。这种多效性表型表明Ehmeth在寄生虫关键细胞过程的控制中起重要作用。
