颅内生殖细胞瘤：生长发育迟缓儿童中一种罕见但重要的鉴别诊断。
Intracranial germinoma: a rare but important differential diagnosis in children with growth retardation.
作者信息
Gottschling Sven, Graf Norbert, Meyer Sascha, Reinhard Harald, Krenn Thomas, Rohrer Tilman
机构信息
Department of Paediatric Haematology and Oncology, University Children's Hospital Homburg, Germany.
出版信息
Acta Paediatr. 2006 Mar;95(3):302-5. doi: 10.1080/08035250500430262.
AIM
Intracranial germinoma is a rare malignant tumour in childhood with an excellent prognosis under adequate therapy. Finding the right diagnosis at an early stage is difficult because of the slow-growing tumour and the resulting lack of clinical symptoms.
METHODS
Our patients with histologically secured germinoma were retrospectively assessed concerning growth retardation, pituitary hormone status, magnetic resonance imaging scan results and clinical symptoms to find out whether there is a leading parameter.
RESULTS
In all our patients, the leading symptom was growth retardation of at least 2 y before being diagnosed.
CONCLUSION
Growth retardation seems to be a very early sign of germinoma in the suprasellar region. Therefore, early neuroradiological imaging combined with pituitary hormone status should be considered in every paediatric patient with a history of secondary growth retardation.
目的
颅内生殖细胞瘤是儿童期罕见的恶性肿瘤，在充分治疗下预后良好。由于肿瘤生长缓慢且缺乏临床症状，早期做出正确诊断较为困难。
方法
对组织学确诊为生殖细胞瘤的患者进行回顾性评估，内容包括生长发育迟缓、垂体激素状态、磁共振成像扫描结果及临床症状，以找出是否存在主导参数。
结果
在我们所有的患者中，主要症状是在确诊前至少2年出现生长发育迟缓。
结论
生长发育迟缓似乎是鞍上区生殖细胞瘤的一个非常早期的迹象。因此，对于每一位有继发性生长发育迟缓病史的儿科患者，都应考虑早期神经放射学成像检查并结合垂体激素状态。
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