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[鞍上及松果体同时发生生殖细胞瘤:一例报告]

[Simultaneous suprasellar and pineal germinoma: a case report].

作者信息

Guerrero-Vázquez S, Armesto-Pérez V, Macía-Suárez D, Branas-Fernández F M

机构信息

Complexo Hospitalario Xeral-Calde, 27004 Lugo, Espana.

出版信息

Rev Neurol. 2008;46(7):411-5.

Abstract

INTRODUCTION

Tumours in the pineal region are rare (0.3-2.7%) and most of the ones that do occur are germ cell tumours, of which germinoma is the most frequent. They are chiefly located in the pineal gland, the next most common being site being the suprasellar region and the fourth ventricle, although simultaneous presentation in these locations is relatively rare (5-10% of cases). The main aim of this study is to review the differential diagnosis of neoplasias in the pineal region.

CASE REPORT

Here we report the case of a 20-year-old male who was admitted to hospital due to irregularities affecting the field of vision, with clinical signs and symptoms of panhypopituitarism and normal levels of tumour markers in blood and cerebrospinal fluid. Magnetic resonance imaging of the craniospinal axis was performed and results showed the presence of two masses with significant enhancement, one located in the pineal region with a signal similar to that of grey matter and the other in the hypothalamus, which had a more heterogeneous aspect with cystic areas inside it. Imaging with paramagnetic contrast agents revealed dissemination with ependymal uptake in relation to the frontal horns and in the fourth ventricle; a possible simultaneous origin was also suggested in this latter location.

CONCLUSIONS

Magnetic resonance imaging plays a decisive role in establishing the diagnosis and therapy plan. The imaging factors that must be taken into account are the origin of the mass, heterogeneity, contrast enhancement, presence of fat or calcium, a signal similar to that of grey matter and possible dissemination, above all into the subarachnoid space. The patient's medical record (age, sex or tumour markers) must also be taken into consideration.

摘要

引言

松果体区肿瘤较为罕见(占0.3 - 2.7%),其中大多数为生殖细胞肿瘤,而生殖细胞瘤最为常见。它们主要位于松果体,其次最常见的部位是鞍上区和第四脑室,不过这些部位同时出现肿瘤相对少见(占病例的5 - 10%)。本研究的主要目的是回顾松果体区肿瘤的鉴别诊断。

病例报告

我们在此报告一例20岁男性患者,因视野异常入院,伴有全垂体功能减退的临床症状和体征,血液及脑脊液中的肿瘤标志物水平正常。对颅脊髓轴进行了磁共振成像检查,结果显示有两个明显强化的肿块,一个位于松果体区,信号与灰质相似,另一个位于下丘脑,表现更为不均质,内部有囊性区域。使用顺磁性造影剂成像显示有播散,在额叶角和第四脑室有室管膜摄取;在后者部位也提示可能有同时起源。

结论

磁共振成像在确立诊断和治疗方案中起决定性作用。必须考虑的成像因素包括肿块的起源、不均质性、对比增强、脂肪或钙的存在、与灰质相似的信号以及可能的播散,尤其是向蛛网膜下腔播散。还必须考虑患者病历(年龄、性别或肿瘤标志物)。

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