Charron Thierry, Nili Nafiseh, Strauss Bradley H
Roy and Ann Foss International Cardiology Research Program, Terrence Donnelly Heart Centre, St Micheal's Hospital, University of Toronto, Ontario.
Can J Cardiol. 2006 Feb;22 Suppl B(Suppl B):41B-55B. doi: 10.1016/s0828-282x(06)70986-2.
Percutaneous coronary intervention is the preferred revascularization approach for most patients with coronary artery disease. However, this strategy is limited by renarrowing of the vessel by neointimal hyperplasia within the stent lumen (in-stent restenosis). Vascular smooth muscle cell proliferation is a major component in this healing process. This process is mediated by multiple cytokines and growth factors, which share a common pathway in inducing cell proliferation: the cell cycle. The cell cycle is highly regulated by numerous mechanisms ensuring orderly and coordinated cell division. The present review discusses current concepts related to regulation of the cell cycle and new therapeutic options that target aspects of the cell cycle.
经皮冠状动脉介入治疗是大多数冠心病患者首选的血运重建方法。然而,这种策略受到支架腔内新生内膜增生导致血管再狭窄(支架内再狭窄)的限制。血管平滑肌细胞增殖是这一愈合过程的主要组成部分。这一过程由多种细胞因子和生长因子介导,它们在诱导细胞增殖方面有一个共同途径:细胞周期。细胞周期受到多种机制的高度调控,以确保细胞分裂有序且协调。本综述讨论了与细胞周期调控相关的当前概念以及针对细胞周期各方面的新治疗选择。