犬脊髓室管膜瘤的手术及放射治疗

Surgical and radiotherapy treatment of a spinal cord ependymoma in a dog.

作者信息

Ueno H, Morimoto M, Kobayashi Y, Hizume T, Murayama N, Uzuka Y

机构信息

Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan.

出版信息

Aust Vet J. 2006 Jan-Feb;84(1-2):36-9. doi: 10.1111/j.1751-0813.2006.tb13121.x.

DOI:10.1111/j.1751-0813.2006.tb13121.x

PMID:16498832

Abstract

A 4-year-old Beagle dog was presented for investigation of a left pelvic limb gait abnormality. Neurolocalisation indicated a lumbar (L2 to L5) spinal cord lesion. On magnetic resonance imaging (MRI), an intramedullary mass was demonstrated at L3. The mass was partially removed under general anaesthesia and a diagnosis of ependymoma was made on histological examination. The dog was treated with postoperative orthovoltage x-ray radiation (total dose; 44 Gy given in 11 fractions over a 4 week period) combined with low dose carboplatin (25 mg/m2). The dog was alive 16 months after surgery without further neurological deficits. No further tumour growth was detected on subsequent MRI evaluations.

摘要

一只4岁的比格犬因左后肢步态异常前来检查。神经定位显示为腰椎（L2至L5）脊髓病变。在磁共振成像（MRI）检查中，L3水平发现髓内肿块。在全身麻醉下对肿块进行了部分切除，并通过组织学检查诊断为室管膜瘤。该犬接受了术后正交电压X线放射治疗（总剂量；4周内分11次给予44 Gy）联合低剂量卡铂（25 mg/m2）治疗。术后16个月该犬存活，无进一步神经功能缺损。在随后的MRI评估中未检测到肿瘤进一步生长。