Griffin John F, Stevenson William S, Nelson Nathan C, Chen Annie V, Hecht Silke, Porter Brian F, Boudreau C Elizabeth, Specchi Swan, Bernardini Marco, Mai Wilfried
Department of Large Animal Clinical Sciences, Texas A&M University, College Station, Texas, USA.
Columbia Veterinary Emergency Trauma and Specialty, Columbia, South Carolina, USA.
Vet Radiol Ultrasound. 2025 Jan;66(1):e13477. doi: 10.1111/vru.13477.
There are few published descriptions of the MRI appearance of canine intracranial or spinal cord ependymoma. In this multicenter, retrospective, secondary analysis, case series study, three veterinary radiologists independently reviewed and recorded imaging characteristics of MRI studies in six dogs with histopathologically confirmed ependymoma (three intracranial and three spinal cord cases). A consensus was reached when there was disagreement on specific features. All intracranial ependymomas had forebrain location, heterogeneous signal intensity in T1-weighted (T1W) and T2-weighted (T2W) images, heterogeneous contrast enhancement, and hyperintensity in T2W images. Two ependymomas had an intraventricular location; one was intra-axial. Other imaging features included intralesional cyst-like structures, intralesional hemorrhage, and perilesional edema. Dogs with spinal cord ependymoma had intramedullary lesions located in the cervical or thoracic spinal cord. Spinal cord ependymomas were isointense and homogeneous in T1W images and hyperintense in T2W images. Lesion location relative to the central canal of the spinal cord was variable. All three spinal cord ependymomas had perilesional T2W hyperintensity and moderate, heterogeneous contrast enhancement. None of the spinal cord ependymomas had intralesional cyst-like structures. One spinal cord ependymoma had evidence of drop metastases (diffuse, leptomeningeal). MRI features of canine ependymomas overlap with those of other diseases of the brain and spinal cord. Ependymoma should be considered a differential diagnosis for dogs with intraventricular, intra-axial forebrain, or intramedullary spinal cord masses.
关于犬颅内或脊髓室管膜瘤的MRI表现，目前发表的描述较少。在这项多中心、回顾性、二次分析的病例系列研究中，三位兽医放射科医生独立审查并记录了6只经组织病理学确诊为室管膜瘤的犬（3例颅内和3例脊髓病例）的MRI研究影像特征。对于特定特征存在分歧时，达成了共识。所有颅内室管膜瘤均位于前脑，在T1加权（T1W）和T2加权（T2W）图像中信号强度不均匀，对比增强不均匀，且在T2W图像中呈高信号。2例室管膜瘤位于脑室内；1例位于脑实质内。其他影像特征包括瘤内囊样结构、瘤内出血和瘤周水肿。患有脊髓室管膜瘤的犬在颈段或胸段脊髓有髓内病变。脊髓室管膜瘤在T1W图像中等信号且均匀，在T2W图像中呈高信号。病变相对于脊髓中央管的位置各不相同。所有3例脊髓室管膜瘤均有瘤周T2W高信号和中等程度、不均匀的对比增强。所有脊髓室管膜瘤均无瘤内囊样结构。1例脊髓室管膜瘤有播散性转移（弥漫性软脑膜转移）的证据。犬室管膜瘤的MRI特征与脑和脊髓的其他疾病有重叠。对于患有脑室内、脑实质内前脑或脊髓髓内肿块的犬，应考虑室管膜瘤作为鉴别诊断。
