Paiva G R, Filho R S O, Ferreira L M, Wagner J, Nogueira S A, Novo N F, Juliano Y, Rocha J L B S
Disciplina de Cirurgia Plástica, Departamento de Cirurgia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brasil.
Acta Radiol. 2006 Feb;47(1):65-70. doi: 10.1080/02841850500406803.
To study which of the two most used radiopharmaceutical drugs for the sentinel lymph node (SLN) biopsy procedure (dextran 500 99mTc and phytate 99mTc) best defines the SLN and migrates less to other lymph nodes.
Thirty-two rats, separated into two groups, underwent lymphoscintigraphy examination with either dextran or phytate followed by sentinel (popliteal), lumbar, and inguinal lymph node biopsy. Radiation was detected with a gamma probe.
The statistical study indicated count rates significantly higher in the SLN than in the other basins for both the dextran (P<0.01) and phytate groups (P<0.001). There was no statistically significant difference concerning SLN absorption in either group (P=0.2981). In the dextran group, migration occurred to 1.5 lymphatic basins with counting higher than 10% of that found in the SLN versus 0.8 in the phytate group (P=0.0023). Migration was thus higher in the dextran group (P=0.0207).
There was no statistically significant difference between dextran and phytate in the SLN identification, but the phytate migrated to fewer lymphatic basins beyond the SLN and with less intensity.
研究在前哨淋巴结（SLN）活检程序中最常用的两种放射性药物（右旋糖酐500 99mTc和植酸盐99mTc）中，哪一种能最好地确定前哨淋巴结且向其他淋巴结的迁移较少。
将32只大鼠分为两组，分别用右旋糖酐或植酸盐进行淋巴闪烁显像检查，随后进行前哨（腘窝）、腰和腹股沟淋巴结活检。用γ探测器检测放射性。
统计研究表明，右旋糖酐组（P<0.01）和植酸盐组（P<0.001）的前哨淋巴结计数率均显著高于其他淋巴结群。两组在前哨淋巴结摄取方面无统计学显著差异（P=0.2981）。在右旋糖酐组中，放射性迁移至1.5个淋巴结群，其计数高于前哨淋巴结计数的10%，而植酸盐组为0.8个（P=0.0023）。因此，右旋糖酐组的迁移率更高（P=0.0207）。
在确定前哨淋巴结方面，右旋糖酐和植酸盐之间无统计学显著差异，但植酸盐向前哨淋巴结以外的淋巴结群迁移的数量更少且强度更低。
