Kogan E A, Kornev B M, Shukurova R A
Arkh Patol. 1991;53(1):60-4.
A case of bronchiolo-alveolar carcinoma (BAC) developing in the presence of idiopathic fibrosing alveolitis (IFA) in a man of 67 with a long history of pulmonary lesion is described. A honeycomb bung was found at the autopsy. Histologically, multiple foci of BAC of mixed-cell structure and those of mucus-producing cells against the background of fibrosing alveolitis at the stage of honeycomb lung were observed. An increased content of collagen type III, IV and V was found immunohistochemically. The role of sclerotic changes and defected immunological surveillance over the epithelial regeneration in the IFA-affected lung in relevant carcinoma genesis is suggested. The origin of the lung carcinoma in IFA is considered to be the regenerating epithelium of the low respiratory tract.
本文描述了一名67岁男性，有长期肺部病变史，在特发性肺纤维化（IFA）基础上发生细支气管肺泡癌（BAC）的病例。尸检发现有蜂窝肺。组织学上，在蜂窝肺阶段的肺纤维化背景下，观察到混合细胞结构的BAC多灶以及黏液产生细胞灶。免疫组化发现III型、IV型和V型胶原含量增加。提示在相关的癌发生过程中，IFA肺中的硬化改变和上皮再生免疫监视缺陷的作用。IFA中肺癌的起源被认为是下呼吸道的再生上皮。
