Isakova L M
Arkh Patol. 1991;53(1):75-9.
The role of human papilloma virus (HPV) in genital cancer is not yet clear at present, but the available data testify to serious changes in cervix uteri epithelium in the process of its infection. Close correlation was demonstrated between HPV type specificity and the degree of epithelial morphological changes as well as histologic tumor variant, and its degree of differentiation. Interrelation between HPV type and level of both regression and progression of atypically changed cervix uteri epithelium is established. Cytomorphological method of the evaluation of cell koilocytotic atypia is the marker to diagnose HPV infection when screening a chosen woman population. The development and introducing of sensitive and reliable identification methods of type-specific DNA sequences of HPV infection in diagnostic material to form a low risk (HPV-6 and II types) and a high risk group (HPV-16 and 18 types) by malignancy of cervix uteri epithelium have considerable promise. It is advisable to study HPV role in the development of adenogenic tumors of uterine cervix and body.
人乳头瘤病毒（HPV）在生殖器癌中的作用目前尚不清楚，但现有数据证明其感染过程中子宫颈上皮发生了严重变化。已证实HPV类型特异性与上皮形态学变化程度、组织学肿瘤变体及其分化程度之间存在密切关联。已确定HPV类型与非典型改变的子宫颈上皮的消退和进展水平之间的相互关系。当对特定女性人群进行筛查时，评估细胞挖空细胞非典型性的细胞形态学方法是诊断HPV感染的标志物。开发并引入灵敏可靠的诊断材料中HPV感染型特异性DNA序列鉴定方法，以根据子宫颈上皮恶性程度将其分为低风险组（HPV - 6和11型）和高风险组（HPV - 16和18型），具有很大的前景。研究HPV在子宫颈和子宫体腺源性肿瘤发生中的作用是可取的。
