Kuhn A, Gensch K, Ständer S, Bonsmann G
Hautklinik der Heinrich-Heine-Universität Düsseldorf.
Hautarzt. 2006 Mar;57(3):251-67; quiz 268. doi: 10.1007/s00105-006-1094-y.
Cutaneous lupus erythematosus (CLE) is a heterogenous disorder with a wide range of skin manifestations. Therefore, it has been difficult to develop a unifying concept for classifying CLE from the dermatologic perspective in the past. In 2004, the classification system was updated and includes now acute CLE (ACLE), subacute CLE (SCLE), chronic CLE (CCLE), and intermittent CLE (ICLE). Additional rarely described variants are not listed as separate entities but are included in the classical forms. Diagnosis of the different subtypes of CLE is made by considering genetic, clinical, histopathologic, and immunoserologic findings, with a systematic analysis of individual criteria. In the past years, the etiology and pathogenesis of CLE has been subject of intensive research and it has been shown by several groups that exogenous factors, such as ultraviolet light and drugs, can induce CLE. The first part of this review will enable the reader to identify the various clinical manifestations of CLE and to employ characteristic criteria to assess differential diagnostic considerations.
皮肤型红斑狼疮（CLE）是一种具有广泛皮肤表现的异质性疾病。因此，过去从皮肤病学角度很难形成一个统一的CLE分类概念。2004年，分类系统进行了更新，现在包括急性CLE（ACLE）、亚急性CLE（SCLE）、慢性CLE（CCLE）和间歇性CLE（ICLE）。其他较少描述的变体未被列为单独的实体，而是包含在经典形式中。CLE不同亚型的诊断是通过综合考虑遗传、临床、组织病理学和免疫血清学结果，并对各项标准进行系统分析来做出的。在过去几年中，CLE的病因和发病机制一直是深入研究的主题，多个研究小组表明，紫外线和药物等外源性因素可诱发CLE。本综述的第一部分将帮助读者识别CLE的各种临床表现，并运用特征性标准来评估鉴别诊断的考量因素。
