Hoda Q, Hasinoff D J, Arbus G S
Clin Nephrol. 1975 Jan;3(1):6-9.
Growth following renal transplantation in children and adolescents. Sixteen children who received a cadaveric renal transplant surviving 1 to 5 years, had their growth rate assessed while receiving 10 to 25 mg of prednisone every 48 hours. Six of 9 patients witha a bone age of 12 years or less grew at a "normal" rate. None of the patients whose bone age was greater than 12 years grew at a "normal" rate. Since low-dose alternate-day prednisone therapy allows for optimal growth but does not appear to compromise kidney survival, we feel such a regime should be instituted in growing children receiving a kidney transplant.
儿童和青少年肾移植后的生长情况。16名接受尸体肾移植且存活1至5年的儿童,在每48小时接受10至25毫克泼尼松治疗期间对其生长速率进行了评估。9名骨龄为12岁或更小的患者中有6名生长速率“正常”。骨龄大于12岁的患者中没有一个生长速率“正常”。由于低剂量隔日泼尼松疗法能实现最佳生长且似乎不会影响肾脏存活,我们认为对于接受肾移植的正在生长的儿童应采用这种治疗方案。