Gosselin Luc E, Williams Jacqueline E
Department of Exercise and Nutrition Sciences, 405 Kimball Tower, University at Buffalo, Buffalo, New York 14214, USA.
Muscle Nerve. 2006 Jun;33(6):820-3. doi: 10.1002/mus.20523.
Fibrosis is a common pathological feature observed in muscle from patients with Duchenne muscular dystrophy and in mdx diaphragm. The purpose of this study was to determine whether pentoxifylline (PTX) treatment for 4 weeks (16 mg/kg/day) could significantly attenuate the process of fibrosis in diaphragm muscle from mdx mice. PTX treatment had no impact on in vitro diaphragm muscle contractile function. In addition, diaphragm muscle hydroxyproline concentration and the level of type I and III collagen and TGF-beta1 mRNA were unaffected by PTX treatment. These findings do not support the use of PTX as an antifibrotic drug for the treatment of muscular dystrophy.
纤维化是杜氏肌营养不良症患者肌肉以及mdx小鼠膈肌中常见的病理特征。本研究的目的是确定4周的己酮可可碱(PTX)治疗(16毫克/千克/天)是否能显著减轻mdx小鼠膈肌的纤维化进程。PTX治疗对体外膈肌肌肉收缩功能没有影响。此外,PTX治疗不影响膈肌肌肉羟脯氨酸浓度、I型和III型胶原蛋白水平以及TGF-β1 mRNA水平。这些发现不支持将PTX用作治疗肌营养不良症的抗纤维化药物。