de Tommaso Marina, Shevel Elliott, Pecoraro Carla, Sardaro Michele, Losito Luciana, Lamberti Paolo, Livrea Paolo
Neurological and Psychiatric Sciences Department University of Bari, Bari, Italy.
Int J Psychophysiol. 2006 Oct;62(1):38-45. doi: 10.1016/j.ijpsycho.2005.12.002. Epub 2006 Feb 28.
In the present study, we examined clinical and laser-evoked potentials (LEP) features in a group of chronic tension-type headache (CTTH) patients, in order to perform a topographic analysis of Laser evoked potentials (LEPs) and a correlation with clinical features. Eighteen patients suffering from CTTH [Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders 2nd ed. Cephalalgia 2004; 24 Suppl 1, 1-159.] participated in the study. Twelve age- and sex-matched controls were also examined. We performed a basal evaluation of clinical features, Total Tenderness Score (TTS) and a topographic analysis of LEPs obtained by the hand and the pericranial points stimulation in all patients vs healthy subjects. The later LEPs, especially the P2 component, were significantly increased in amplitude in the CTTH group, specially when the pericranial points were stimulated. The P2 wave amplitude was correlated with TTS levels and anxiety scores. The results of this study confirm that pericranial tenderness is a phenomenon initiating a self-sustaining circuit, involving central sensitization at the level of the cortical nociceptive areas devoted to attentional and emotional components of pain.
在本研究中，我们检查了一组慢性紧张型头痛（CTTH）患者的临床和激光诱发电位（LEP）特征，以便对激光诱发电位（LEPs）进行地形图分析，并将其与临床特征进行关联。18名患有CTTH的患者[国际头痛协会头痛分类小组委员会。《国际头痛疾病分类》第2版。头痛2004；24增刊1，1 - 159。]参与了该研究。还检查了12名年龄和性别匹配的对照者。我们对所有患者与健康受试者进行了临床特征的基础评估、总压痛评分（TTS）以及通过手部和颅周点刺激获得的LEPs的地形图分析。在CTTH组中，后期的LEPs，尤其是P2成分，在刺激颅周点时，其振幅显著增加。P2波振幅与TTS水平和焦虑评分相关。本研究结果证实，颅周压痛是一种启动自我维持回路的现象，涉及在致力于疼痛的注意力和情感成分的皮质伤害性感受区域水平的中枢敏化。
