[人膜联蛋白V在不同胎儿组织中的表达]

[Expression of human annexin V in different fetal tissues].

作者信息

Ye Feng, Li Shu-hong, Chen Tian-yan, Yue Ya-fei, Zhang Shu-lin, Bai Gui-qin

机构信息

Department of Infectious Disease, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2006 Feb;26(2):193-5.

PMID:16503527

Abstract

OBJECTIVE

To investigate the expression of human annexin-V (HA-V) in relation to HBV infection in different fetal tissues.

METHODS

Immunohistochemistry was employed to detect the expression and distribution of HA-V in the liver, kidney, ovary, heart, fallopian tube, spleen, and thymus gland of human fetus.

RESULTS

HA-V expression was detected in different tissues including the ovary, liver, intrahepatic bile duct, heart, kidney, lymphocytic cells in the thymus gland, epithelial cells of the fallopian, and cortical and medullary cells of the spleen. HA-V was distributed mainly in the cytoplasm of the cells. The liver tissues exhibited greater gray scale for HA-V expression than in the other tissues (P<0.05) and no significant difference was observed in the other tissues than the liver (P>0.05) in image analysis with Photoshop 7.0.

CONCLUSION

HA-V is an inherent protein in fetal tissues with possible relation to HBV infection of different tissues as a HBV receptor. Greater amount of HA-V in the liver may account for the vulnerability of the liver to HBV infection.

摘要

目的

研究人膜联蛋白-V（HA-V）在不同胎儿组织中的表达及其与乙型肝炎病毒（HBV）感染的关系。

方法

采用免疫组织化学法检测HA-V在人胎儿肝脏、肾脏、卵巢、心脏、输卵管、脾脏和胸腺中的表达及分布。

结果

在卵巢、肝脏、肝内胆管、心脏、肾脏、胸腺中的淋巴细胞、输卵管上皮细胞以及脾脏的皮质和髓质细胞等不同组织中均检测到HA-V的表达。HA-V主要分布于细胞的细胞质中。肝脏组织中HA-V表达的灰度值高于其他组织（P<0.05），使用Photoshop 7.0进行图像分析时，除肝脏外其他组织之间未观察到显著差异（P>0.05）。