Braun Felix, Behrend Matthias
General and Transplantation Surgery, University of Kiel, Germany.
Expert Opin Investig Drugs. 2006 Mar;15(3):267-91. doi: 10.1517/13543784.15.3.267.
Immunosuppressive drugs are the backbone of solid organ transplantation. The introduction of new immunosuppressive drugs led to improved patient and organ survival rates. Nowadays, acute rejection can be reduced to a minimum. Individualization and avoidance of drug-related adverse effects became a new goal to achieve. The potency of immunosuppressive drugs makes them attractive for use in various autoimmune diseases; therefore, the experience on immunosuppressive drugs outside the field of organ transplantation is analysed in this review.
免疫抑制药物是实体器官移植的支柱。新型免疫抑制药物的引入提高了患者生存率和器官存活率。如今，急性排斥反应可降至最低。实现个体化给药并避免药物相关不良反应成为了新的目标。免疫抑制药物的效力使其在各种自身免疫性疾病中具有应用吸引力；因此，本综述分析了器官移植领域以外使用免疫抑制药物的经验。
