Montgomery B T, Kelalis P P, Blute M L, Bergstralh E J, Beckwith J B, Norkool P, Green D M, D'Angio G J
Mayo Clinic, Rochester, Minnesota 55905.
J Urol. 1991 Aug;146(2 ( Pt 2)):514-8. doi: 10.1016/s0022-5347(17)37840-0.
The long-term survival of patients with synchronous bilateral Wilms tumor is not well defined. Retrospective review of 185 patients registered with the National Wilms Tumor Study from January 1974 to July 1986 with stage V tumors suggests that the long-term outcome remains good. Over-all survival is 83%, 73% and 70% at 2, 5 and 10 years, respectively. Unfavorable histology, age at diagnosis and the most advanced stage of the individual tumors remain the most important prognostic variables. No significant difference in survival was noted between patients undergoing initial surgical resection of the tumor and those managed with initial tumor biopsy followed by chemotherapy with or without radiotherapy and subsequent surgical resection. Survival does not appear to be compromised by attempting to conserve native renal function with renal-sparing operations.
同步双侧肾母细胞瘤患者的长期生存情况尚未明确界定。对1974年1月至1986年7月在国家肾母细胞瘤研究中登记的185例Ⅴ期肿瘤患者进行的回顾性研究表明，长期预后仍然良好。2年、5年和10年的总体生存率分别为83%、73%和70%。不良组织学类型、诊断时的年龄以及单个肿瘤的最晚期别仍然是最重要的预后变量。在接受肿瘤初始手术切除的患者与接受初始肿瘤活检，然后进行化疗（无论是否联合放疗）及后续手术切除的患者之间，生存率没有显著差异。通过保留肾手术试图保留肾功能似乎不会影响生存率。
