Early results of orthotopic liver transplantations using the technique of inferior vena cava anastomosis.

INTRODUCTION

We compared early results of orthotopic liver transplantation (OLT) in adults using the classic versus piggyback technique of inferior vena cava anastomosis.

PATIENTS AND METHODS

We analyzed 100 consecutive patients who underwent OLT from 2000 to 2003. Group A included 50 patients operated with the classic technique with venovenous extracorporeal bypass, and group B, 50 patients with the piggyback technique. The age range of the patients in group A was 21 to 63 years (mean, 43.5 years) and in group B, 20 to 65 years (mean, 46 years). The gender F/M distribution in group A was 24/26 and in group B, 28/22. The indications for OLT were acute hepatic failure (8%), chronic liver insufficiency (77%), liver tumors (8%), metabolic diseases (5%), and Budd-Chiari syndrome (2%). The degrees of liver insufficiency evaluated according to the Child classification were A, 18; B, 52; and C, 30 patients. The urgency for OLT on the United Network for Organ Sharing (UNOS) scale was UNOS 1-group A, 2 patients; group B, 7 patients; UNOS 2a-group A, 7 patients; group B, 6 patients; UNOS 2b-group A, 29 patients; group B, 30 patients; UNOS 3-group A, 12 patients; group B, 7 patients.

RESULTS

The average cold ischemia time in group A was 530 minutes and in group B, 515 minutes. The average results on the 10th postoperative day: aspartate transaminase (AST)-group A, 52.5 U/L; group B, 54.5 U/L; alanine transaminase (ALT)-group A, 131.5 U/L; group B, 153 U/L; gamma glutyl transpeptidase (GGTP)-group A, 299 U/L; group B, 285.5 U/L; alkaline phosphatase (ALP)-group A, 164 U/L; group B, 150.5 U/L; bilirubin-group A, 4.37 mg%; group B, 2.71 mg%; activated partial thromboplastin time (APTT)-group A, 37.6 seconds; group B, 34.8 seconds; platelets (PLT)-group A, 167 10(2)/mm(2); group B, 171 10(2)/mm(2). The incidence of postoperative complications was 36% in group A; it was 30% in group B. The mean hospitalization times in the surgical department were 17 days in group A and 16 days in group B.

CONCLUSIONS

The early results, morbidity and mortality with both applied techniques were similar. Individualization in qualifying the patients for a given operative technique is important. The lower complication rate and reduced treatment cost of the piggyback technique group suggested advantages of this technique when compared with the classical OLT technique.