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一项关于采用贝尔吉蒂改良背驮式技术进行500例肝移植的单中心经验。

A single-center experience of 500 liver transplants using the modified piggyback technique by Belghiti.

作者信息

Mehrabi Arianeb, Mood Zhoobin A, Fonouni Hamidreza, Kashfi Arash, Hillebrand Norbert, Müller Sascha A, Encke Jens, Büchler Markus W, Schmidt Jan

机构信息

Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

出版信息

Liver Transpl. 2009 May;15(5):466-74. doi: 10.1002/lt.21705.

Abstract

Over the past 4 decades, the surgical techniques of liver transplantation (LTx) have permanently evolved and been modified. Among these, the modified piggyback (MPB) technique by Belghiti offers specific advantages. The objective of this study was to present our single-center experience with the MPB technique in 500 cases. Recipients' perioperative data were prospectively collected and evaluated. Postoperative and specific complications, stay in the intensive and intermediate care unit, and the mortality rate with cause of death were analyzed. Most recipients were classified as Child C (49.1%). For the patients who underwent LTx for the first time, alcoholic (23.9%) and viral (22.2%) cirrhosis and hepatocellular carcinoma (15.1%) were the prevalent indications. The overall median warm ischemia time, anastomosis duration, and operative time were 45, 108, and 320 minutes, respectively. The median intraoperative blood loss was 1500 mL. A venovenous bypass was never needed to maintain hemodynamic stability. Only in a few cases was temporary inferior vena cava clamping necessary. Most prominent surgical complications were hemorrhage, hematoma, and wound dehiscence. Renal failure occurred in 6.2% of patients. The overall median stay in the intensive and intermediate care unit was 14 days. The mortality rates within 30 and 90 days were 6.3% and 13.3%, respectively. No technique-related death occurred. The MPB technique by Belghiti is a feasible and simple LTx technique. The caval flow is preserved during the anhepatic phase, and this minimizes the need for venovenous bypass or portocaval shunt. This technique requires only 1 caval anastomosis, which is easy to perform with a short anhepatic phase. To minimize the risk of outflow obstruction, attention should be paid by doing a wide cavocavostomy cranially to the donor inferior vena cava in a door-lock manner. This technique can be applied in almost all patients undergoing LTx for the first time and liver retransplantation as well.

摘要

在过去的40年里,肝移植(LTx)的手术技术不断发展并得到改进。其中,Belghiti提出的改良背驮式(MPB)技术具有独特优势。本研究的目的是介绍我们单中心500例MPB技术的经验。前瞻性收集并评估受者的围手术期数据。分析术后及特定并发症、在重症监护和中级护理病房的住院时间以及死亡率和死亡原因。大多数受者被归类为Child C级(49.1%)。首次接受肝移植的患者中,酒精性(23.9%)和病毒性(22.2%)肝硬化以及肝细胞癌(15.1%)是常见的适应证。总体中位热缺血时间、吻合时间和手术时间分别为45分钟、108分钟和320分钟。术中中位失血量为1500毫升。从未需要静脉-静脉转流来维持血流动力学稳定。仅在少数情况下需要临时阻断下腔静脉。最突出的手术并发症是出血、血肿和伤口裂开。6.2%的患者发生肾衰竭。在重症监护和中级护理病房的总体中位住院时间为14天。30天和90天内的死亡率分别为6.3%和13.3%。未发生与技术相关的死亡。Belghiti的MPB技术是一种可行且简单的肝移植技术。在无肝期保留腔静脉血流,这最大限度地减少了对静脉-静脉转流或门腔分流的需求。该技术仅需1次腔静脉吻合,易于操作且无肝期短。为了将流出道梗阻的风险降至最低,应采用门锁式在供体下腔静脉头侧进行广泛的腔静脉吻合术。该技术几乎可应用于所有首次接受肝移植和再次肝移植的患者。

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