Jabiry-Zieniewicz Z, Kamiński P, Pietrzak B, Cyganek A, Bobrowska K, Ziółkowski J, Ołdakowska-Jedynak U, Zieniewicz K, Paczek L, Jankowska I, Wielgoś M, Krawczyk M
First Department of Obstetrics and Gynecology, Warsaw Medical University, Pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland.
Transplant Proc. 2006 Jan-Feb;38(1):255-7. doi: 10.1016/j.transproceed.2005.12.044.
Pregnancies in women after liver transplantation are considered high risk due to the greater rate of complications observed in immunosuppressed graft recipients. We report successful outcomes of four high-risk pregnancies in female liver transplant recipients on tacrolimus-based immunosuppression. The patients, aged 23 to 32 years, at the time of conception were 12 to 59 months from transplantation (mean 30 months). Preterm labor was the most important pregnancy complication observed in these patients. One episode of acute graft rejection was observed. A variable demand for tacrolimus was noted during pregnancy. Despite complications all four pregnancies were successful. The mean gestational age at delivery was 34.4 weeks. The birth weight of the newborns varied from 1410 to 3490 g (mean 2303 g) and the mean Apgar score was 8. No structural malformations or early complications were observed in the newborns. Excluding the patient with acute rejection, the remaining three cases showed all liver parameters to remain stable.
由于免疫抑制的移植受者中观察到的并发症发生率较高，肝移植术后女性怀孕被认为是高风险的。我们报告了4例接受基于他克莫司免疫抑制治疗的女性肝移植受者的高风险妊娠成功结局。这些患者年龄在23至32岁之间，受孕时距离移植手术12至59个月（平均30个月）。早产是这些患者中观察到的最重要的妊娠并发症。观察到1次急性移植排斥反应。孕期对他克莫司的需求各不相同。尽管有并发症，所有4次妊娠均成功。分娩时的平均孕周为34.4周。新生儿出生体重在1410至3490克之间（平均2303克），平均阿氏评分8分。新生儿未观察到结构畸形或早期并发症。除急性排斥反应患者外，其余3例所有肝脏指标均保持稳定。
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