Zahra Tayebi, Seyyed Alireza Taqhavi, Shirin Shahbazi
Namazi Educational Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
J Reprod Infertil. 2009 Oct;10(3):225-9.
Pregnancy and parenting have been part of human life throughout history and liver transplant recipients are not any exception. This paper reports successful pregnancies in two liver transplant recipients in Iran.
The first case was a 34-year old woman who had undergone orthotopic liver transplantation (OLT) at Shiraz Namazi Educational Hospital in 2002. She decided to get pregnant seven years after the operation. During pregnancy, immunosuppressive therapy continued, except Mycophenolate Mofetil which has an absolute contra-indication in pregnancy. The patient was followed up during pregnancy by the transplant team as well as a gynecologist. She faced no significant complications and the liver function was stable during pregnancy. She later underwent a Cesarean section in the 38(th) week of gestation and the newborn was a healthy girl weighing 2480g with an Apgar score of 8 at the time of birth. There were no evidences of prematurity or structural abnormalities in the newborn. The second case was a 31-year old primipara who had received an orthotopic liver transplant (OLT) in Shiraz in 2002. She had a smooth pregnancy without any complications and the newborn was a boy weighing 3100g with Apgar scores of 8 and 10 at the time of birth and 5 minutes thereafter, respectively.
As the number of transplant recipients is growing along with the number of recipients who are in their fertility years, it is vital to ensure a proper medical care by a coordinated multidisciplinary team during pregnancy.
怀孕和为人父母贯穿人类历史,肝移植受者也不例外。本文报告了伊朗两名肝移植受者成功怀孕的案例。
第一个病例是一名34岁女性,2002年在设拉子纳马齐教育医院接受了原位肝移植(OLT)。她在术后七年决定怀孕。孕期继续进行免疫抑制治疗,但停用了在孕期有绝对禁忌证的霉酚酸酯。孕期移植团队和妇科医生对患者进行了随访。她未出现重大并发症,孕期肝功能稳定。她后来在妊娠38周时进行了剖宫产,新生儿是一名健康女婴,出生时体重2480克,阿氏评分8分。新生儿无早产或结构异常迹象。第二个病例是一名31岁初产妇,2002年在设拉子接受了原位肝移植(OLT)。她孕期顺利,无任何并发症,新生儿是一名男婴,出生时体重3100克,出生时阿氏评分8分,出生后5分钟阿氏评分10分。
随着移植受者数量以及处于生育年龄的受者数量不断增加,孕期由多学科协作团队提供恰当医疗护理至关重要。