Karwacka E, Ołdakowska-Jedynak U, Brydak-Godowska J, Paczek L, Kecik D
Department of Ophthalmologic Disorders, Warsaw Medical University, ul. Lindleya 4, 02-006 Warsaw, Poland.
Transplant Proc. 2006 Jan-Feb;38(1):292-4. doi: 10.1016/j.transproceed.2005.12.035.
We present two patients who developed keratitis sicca and pemphigoid-like symptoms following allogeneic bone marrow transplantation (BMT). The diagnosis of ocular graft-versus-host disease (GvHD) was considerably delayed in both. They were admitted to the reference ophthalmology and posttransplant care departments years after allogeneic BMT, when skin biopsy revealed changes typical for chronic GvHD. In both cases either systemic or local immunosuppressive treatment led to improvement of the clinical condition but did not significantly change patients' quality of life.
我们报告了两名在异基因骨髓移植（BMT）后出现干燥性角膜炎和类天疱疮样症状的患者。两名患者的眼部移植物抗宿主病（GvHD）诊断均被显著延迟。他们在异基因BMT数年之后才被收入眼科和移植后护理参考科室，此时皮肤活检显示出慢性GvHD的典型变化。在这两个病例中，全身或局部免疫抑制治疗均使临床状况有所改善，但并未显著改变患者的生活质量。
