Skolnik P R, Jahn B, Wang M Z, Rota T R, Hirsch M S, Krane S M
Department of Medicine, Tufts University School of Medicine, Boston, MA.
Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6632-6. doi: 10.1073/pnas.88.15.6632.
Human immunodeficiency virus (HIV) expression and replication are under tight regulatory control. We demonstrate that 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] enhances the replication of monocyte- and lymphocyte-tropic strains of HIV-1 up to 10,000-fold in monocyte cell lines, peripheral blood monocytes, and unfractionated peripheral blood mononuclear cells. 1,25(OH)2D3 is therefore one of the most potent regulators of HIV-1 replication described to date. Precursors of 1,25(OH)2D3 enhance HIV-1 replication in proportion to their affinity for the 1,25(OH)2D3 intracellular receptor, suggesting that 1,25(OH)2D3 influences HIV-1 replication by mechanisms involving this receptor. These studies may have important implications for the design of effective therapy of HIV-1 infection.
人类免疫缺陷病毒（HIV）的表达和复制受到严格的调控。我们证明，1,25-二羟基胆钙化醇[1,25-(OH)₂D₃]可使HIV-1单核细胞嗜性和淋巴细胞嗜性毒株在单核细胞系、外周血单核细胞及未分离的外周血单个核细胞中的复制增强达10000倍。因此，1,25(OH)₂D₃是迄今为止所描述的最有效的HIV-1复制调节因子之一。1,25(OH)₂D₃的前体增强HIV-1复制的程度与其对1,25(OH)₂D₃细胞内受体的亲和力成正比，这表明1,25(OH)₂D₃通过涉及该受体的机制影响HIV-1复制。这些研究可能对设计有效的HIV-1感染治疗方法具有重要意义。
