Schumacher H Ralph, Chen Lan X
Division of Rheumatology, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.
Rheum Dis Clin North Am. 2006 Feb;32(1):235-44, xii. doi: 10.1016/j.rdc.2005.10.003.
Newer approaches to the treatment of gout have included modifications and further attention to aspects of current therapies, and development of interesting new therapies. Colchicine prophylaxis appears to be needed longer than previously recognized after introduction of a urate-lowering agent. Diet has received attention, though most dietary effects are small. New agents under investigation include pegylated formulations of uricase and a new potent xanthine oxidase inhibitor, febuxostat. Some cardiovascular drugs have been shown to be uricosuric.
痛风治疗的新方法包括对现有疗法的改进和进一步关注，以及开发有趣的新疗法。在引入降尿酸药物后，秋水仙碱预防似乎需要比以前认识到的更长时间。饮食受到了关注，尽管大多数饮食影响较小。正在研究的新药物包括聚乙二醇化尿酸酶制剂和一种新的强效黄嘌呤氧化酶抑制剂非布司他。一些心血管药物已被证明具有促尿酸排泄作用。
