利用荧光团标记配体的苯二氮䓬受体非同位素受体结合测定法。
Nonisotopic receptor-binding assay for benzodiazepine receptors utilizing a fluorophore labeled ligand.
作者信息
Takeuchi T, Rechnitz G A
机构信息
Hawaii Biosensor Laboratory, Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822.
出版信息
Anal Biochem. 1991 May 1;194(2):250-5. doi: 10.1016/0003-2697(91)90226-j.
A nonisotopic receptor-binding assay method provides a new approach for the study of receptor-ligand interactions and a possible receptor assay for benzodiazepine drugs. The proposed method is based upon the use of fluorescence-labeled drugs and a chromatographic system which accepts samples without deproteinization. The effectiveness of the technique is illustrated in a study of benzodiazepine receptor-drug-binding interactions.
一种非同位素受体结合测定方法为研究受体-配体相互作用提供了新途径，也为苯二氮䓬类药物提供了一种可能的受体测定方法。所提出的方法基于使用荧光标记药物和无需脱蛋白即可接受样品的色谱系统。该技术的有效性在一项关于苯二氮䓬受体-药物结合相互作用的研究中得到了体现。
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