耐甲氧西林金黄色葡萄球菌的患病率及抗菌药物敏感性模式：一项多中心研究

Prevalence and antimicrobial susceptibility pattern of methicillin resistant Staphylococcus aureus: a multicentre study.

作者信息

Rajaduraipandi K, Mani K R, Panneerselvam K, Mani M, Bhaskar M, Manikandan P

机构信息

Department of Microbiology, Dr. GR Damodaran College of science, Coimbatore- 641 014, Tamilnadu, India.

出版信息

Indian J Med Microbiol. 2006 Jan;24(1):34-8. doi: 10.4103/0255-0857.19892.

DOI:10.4103/0255-0857.19892

PMID:16505553

Abstract

PURPOSE

Methicillin resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen. We report the prevalence and antibiotic susceptibility pattern of MRSA in major southern districts of Tamilnadu.

METHODS

A total of 7172 clinical specimens and 1725 carrier screening samples were collected from different centers and subjected to MRSA screening using conventional microbiological methods. Subsequently the antibiotic sensitivity test was performed for the confirmed MRSA isolates.

RESULTS

Out of 906 strains of S. aureus isolated from clinical and carrier samples, 250 (31.1%) and 39 (37.9%) were found to be methicillin resistant respectively. Almost all clinical MRSA strains (99.6%) were resistant to penicillin, 93.6% to ampicillin, and 63.2% towards gentamicin, co-trimoxazole, cephalexin, erythromycin, and cephotaxime. All MRSA strains (100%) of carrier screening samples had resistance to penicillin and about 71.8% and 35.9% were resistant to ampicillin and co-trimoxazole respectively. Multidrug resistance was observed among 63.6% of clinical and 23% of carrier MRSA isolates. However, all strains of clinical and carrier subjects were sensitive to vancomycin.

CONCLUSION

The determination of prevalence and antibiotic sensitivity pattern of MRSA will help the treating clinicians for first line treatment in referral hospitals.

摘要

目的

耐甲氧西林金黄色葡萄球菌（MRSA）是一种重要的医院病原体。我们报告了泰米尔纳德邦南部主要地区MRSA的流行情况和抗生素敏感性模式。

方法

从不同中心共收集了7172份临床标本和1725份携带者筛查样本，采用传统微生物学方法进行MRSA筛查。随后对确诊的MRSA分离株进行抗生素敏感性试验。

结果

从临床和携带者样本中分离出的906株金黄色葡萄球菌中，分别有250株（31.1%）和39株（37.9%）被发现耐甲氧西林。几乎所有临床MRSA菌株（99.6%）对青霉素耐药，93.6%对氨苄西林耐药，63.2%对庆大霉素、复方新诺明、头孢氨苄、红霉素和头孢噻肟耐药。携带者筛查样本中的所有MRSA菌株（100%）对青霉素耐药，分别约有71.8%和35.9%对氨苄西林和复方新诺明耐药。63.6%的临床MRSA分离株和23%的携带者MRSA分离株存在多重耐药。然而，临床和携带者受试者的所有菌株对万古霉素敏感。