Macho L, Kolena J
Endocrinol Exp. 1975 Jun;9(2):93-9.
The content of cAMP, the release of glycerol and nonesterified fatty acids (NEFA) of adipose tissue with and without the stimulation by ACTH and norepinephrine were determined in young and old rats. After the lipid mobilizing hormones lowered concentration of cAMP and impaired stimulation of lipolytic activity were found in old rats. Furthermore, less stimulation of glycerol and NEFA release by cAMP was observed in these animals. These results suggested that in old animals a lower lipolytic activity per tissue and lipid mass is available in intact and hormone stimulated fat tissue and therefore the accumulation of lipids in fat depots is facilitated.
测定了年轻和老年大鼠脂肪组织在有或无促肾上腺皮质激素（ACTH）和去甲肾上腺素刺激下的环磷酸腺苷（cAMP）含量、甘油和非酯化脂肪酸（NEFA）的释放量。发现脂解激素降低cAMP浓度并损害脂解活性后，老年大鼠出现这种情况。此外，在这些动物中观察到cAMP对甘油和NEFA释放的刺激作用较小。这些结果表明，在老年动物中，完整的和激素刺激的脂肪组织中每组织和脂质质量的脂解活性较低，因此促进了脂肪库中脂质的积累。
