Dhingra V K, Rajpal S, Aggarwal Nishi, Aggarwaln J K, Shadab Khan, Jain S K
New Delhi Tuberculosis Centre, Jawaharlal Nehru Marg, New Delhi-110 002.
J Commun Dis. 2004 Dec;36(4):251-9.
A total of 8.37% of the 1195 patients treated at NDTB Centre with DOTS under RNTCP between January 2002 to June 2003 presented with adverse drug reactions. Patients showing any sort of adverse reactions were studied in detail by personal interviews and a semi-structured questionnaire. The profile of patients presenting with adverse reactions showed that majority of the patients (53%) had gastrointestinal reactions, the commonest presenting complaint being nausea and vomiting. General aches and pains were complained by about 35% and giddiness was the presenting complaint in 27% irrespective of the use of streptomycin, although giddiness was observed more often in Category II patients (59%). Skin rash and itching was complained by about 17% of patients and 11% complained of arthralgia, while only 1% had hepatotoxicity during treatment. Majority of the adverse reactions (67%) were observed within the first four weeks of treatment and only 0.25% of patients treated with DOTS had interruption of treatment for short periods.
2002年1月至2003年6月期间，在国家结核病防治中心接受“直接观察短程疗法”（DOTS）治疗的1195例患者中，共有8.37%出现了药物不良反应。通过个人访谈和半结构化问卷对出现任何不良反应的患者进行了详细研究。出现不良反应的患者情况显示，大多数患者（53%）有胃肠道反应，最常见的主诉是恶心和呕吐。约35%的患者主诉全身疼痛，27%的患者主诉头晕，无论是否使用链霉素均如此，不过在二类患者中头晕更为常见（59%）。约17%的患者主诉皮疹和瘙痒，11%的患者主诉关节痛，而治疗期间仅有1%的患者出现肝毒性。大多数不良反应（67%）在治疗的前四周内出现，接受DOTS治疗的患者中仅有0.25%的患者出现短期治疗中断。
