Chen J M, Gu Q L
Research Division of Hematology, Suzhou Medical College.
Zhonghua Nei Ke Za Zhi. 1991 Feb;30(2):98-100, 120.
Intracellular contents and serum levels of neutrophilic granule protein components, including myeloperoxidase (MPO), lactoferrin (LF) and lysozyme (LYZ), were investigated in 30 cases of myelodysplastic syndromes (MDS), with 59 healthy adult donors as controls. Both neutrophilic MPO and LF decreased significantly, suggesting the transformation of abnormal clones. Both serum levels of LF and LYZ exhibited a considerable fluctuation which may reflect reflect granulopoiesis in the bone marrow. We are of the opinion that measurement of intracellular MPO, LF, LYZ and their serum levels may aid in the diagnosis and prognosis of MDS and is proved to be of great clinical significance.
对30例骨髓增生异常综合征（MDS）患者及59名健康成年供者进行研究，检测中性粒细胞颗粒蛋白成分（包括髓过氧化物酶（MPO）、乳铁蛋白（LF）和溶菌酶（LYZ））的细胞内含量及血清水平。中性粒细胞MPO和LF均显著降低，提示异常克隆的转化。LF和LYZ的血清水平均呈现较大波动，这可能反映了骨髓中的粒细胞生成情况。我们认为，检测细胞内MPO、LF、LYZ及其血清水平可能有助于MDS的诊断和预后评估，且已证明具有重要的临床意义。
