Huot S J, Aronson P S
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Diabetes Care. 1991 Jun;14(6):521-35. doi: 10.2337/diacare.14.6.521.
The Na(+)-H+ exchanger is a ubiquitous transport system that is involved in the regulation of intracellular pH, cell growth and proliferation, cell volume regulation, and transepithelial absorption of Na+, Cl-, and HCO3-. Altered activity of the Na(+)-H+ exchanger has been implicated as a mechanism contributing to the development of high blood pressure in subgroups of patients with essential hypertension and in various animal models of hypertension. Many of these studies measured Na(+)-Li+ exchange rather than Na(+)-H+ exchange, hypothesizing that Na(+)-Li+ exchange represents a functional mode of the Na(+)-H+ exchanger. However, this is a controversial assumption. Several studies have also shown an association between erythrocyte Na(+)-Li(+)-exchange rate and predisposition to nephropathy in patients with insulin-dependent diabetes mellitus. The recent cDNA cloning of at least one isoform of the Na(+)-H+ exchanger will help clarify the cellular mechanisms of regulation of the exchanger and its possible role in pathophysiological states such as hypertension.
钠氢交换体是一种普遍存在的转运系统，参与细胞内pH值调节、细胞生长与增殖、细胞容积调节以及钠、氯和碳酸氢根的跨上皮吸收。钠氢交换体活性改变被认为是原发性高血压患者亚组以及各种高血压动物模型中高血压发生发展的一种机制。许多此类研究测量的是钠锂交换而非钠氢交换，推测钠锂交换代表了钠氢交换体的一种功能模式。然而，这是一个有争议的假设。多项研究还表明，胰岛素依赖型糖尿病患者的红细胞钠锂交换率与肾病易感性之间存在关联。最近对钠氢交换体至少一种亚型进行的cDNA克隆将有助于阐明该交换体的细胞调节机制及其在高血压等病理生理状态中可能发挥的作用。
