Criss W E, Morris H P
Enzyme. 1975;20(2):65-70. doi: 10.1159/000458921.
Rat liver cAMP phosphodiesterase has been fractionated into four peaks of activity with isoelectrofocusing column chromatography. The major two liver peaks (high Km enzymes) decreased with increasing growth rate while the minor two liver peaks (low Km enzymes) increased in one fast growing Morris hepatoma. There was also less total phosphodiesterase activity in the fast growing hepatoma.
用等电聚焦柱色谱法将大鼠肝脏环磷酸腺苷磷酸二酯酶分离成四个活性峰。肝脏中的两个主要峰（高Km酶）随着生长速率的增加而降低，而在一种快速生长的莫里斯肝癌中，肝脏中的两个较小峰（低Km酶）增加。快速生长的肝癌中总的磷酸二酯酶活性也较低。
