尼泊尔苔草中的新白藜芦醇低聚物尼泊尔苔草素D - G作为DNA拓扑异构酶II的有效抑制剂（莎草科）

Nepalensinols D-G, new resveratrol oligomers from Kobresia nepalensis (Cyperaceae) as potent inhibitors of DNA topoisomerase II.

作者信息

Yamada Masashi, Hayashi Ken-Ichiro, Hayashi Hiroshi, Tsuji Ryota, Kakumoto Kazuyuki, Ikeda Shogo, Hoshino Takuji, Tsutsui Ken, Tsutsui Kimiko, Ito Tetsuro, Iinuma Munekazu, Nozaki Hiroshi

机构信息

Meiji Dairies Corporation, Shinsuna, Tokyo, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2006 Mar;54(3):354-8. doi: 10.1248/cpb.54.354.

DOI:10.1248/cpb.54.354

PMID:16508191

Abstract

Four new resveratrol oligomers, nepalensinols D-G, were isolated from the stem of Kobresia nepalensis (Cyperaceae). The structures were determined by detailed NMR spectral analysis. The compounds were assessed for their inhibitory activity against human topoisomerase II, a potential target of anti-tumor agents. These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5-15 microM.

摘要

从尼泊尔嵩草（莎草科）的茎中分离出四种新的白藜芦醇低聚物，即尼泊尔嵩草醇D-G。通过详细的核磁共振光谱分析确定了其结构。评估了这些化合物对人拓扑异构酶II的抑制活性，人拓扑异构酶II是抗肿瘤药物的一个潜在靶点。这些芪类化合物对人拓扑异构酶II显示出强效抑制活性，IC50值为5-15微摩尔。