使用多相可循环催化剂从森田-贝利斯-希尔曼加合物高效合成2-苯并氧杂卓。

An efficient synthesis of 2-benzoxepines from Morita-Baylis-Hillman adducts using heterogeneous recyclable catalysts.

作者信息

Das Biswanath, Majhi Anjoy, Banerjee Joydeep, Chowdhury Nikhil, Holla Harish, Harakishore Kankipati, Murty Upadhayula Suryanarayana

机构信息

Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad, India.

出版信息

Chem Pharm Bull (Tokyo). 2006 Mar;54(3):403-5. doi: 10.1248/cpb.54.403.

DOI:10.1248/cpb.54.403

PMID:16508203

Abstract

2-Benzoxepines have efficiently been synthesized from Morita-Baylis-Hillman adducts, alkyl 3-aryl-3-hydroxy-2-methylenepropanoates by treatment with HCHO catalyzed by silica supported perchloric acid (HClO4.SiO2) or Amberlyst-15 in CH2Cl2 under reflux for a short period of time (1.5-2.5 h). The catalyst can be recovered and recycled. The antibacterial properties of the new 2-benzoxepines were studied but no activity was found.

摘要

通过在二氯甲烷中回流短时间（1.5 - 2.5小时），用硅胶负载的高氯酸（HClO4.SiO2）或Amberlyst - 15催化甲醛处理3 - 芳基 - 3 - 羟基 - 2 - 亚甲基丙酸烷基酯（Morita - Baylis - Hillman加合物），已高效合成了2 - 苯并氧杂卓。该催化剂可以回收并循环使用。对新型2 - 苯并氧杂卓的抗菌性能进行了研究，但未发现活性。