Mathela Chandra S, Singh Krishna K, Gupta Vivek K
Department of Chemistry, Kumaun University, Nainital 263 002, India.
Acta Pol Pharm. 2010 Jul-Aug;67(4):375-80.
Fourteen esters of thymol and carvacrol were synthesized and characterized on the basis of spectral data. The NMR data for some of these are being given for the first time. The antibacterial activity screening of thymol, carvacrol and their esters were carried out against four Gram-positive (Streptococcus mutans MTCC 890, Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 121, Staphylococcus epidermidis MTCC 435) and one Gram-negative (Escherichia coli MTCC 723) bacteria. The enhancement in activity was noticed in the thymyl ester derivatives 4a-c (against S. mutans, B. subtilis and S. epidermidis) in comparison to thymol, whereas the carvacrol derivatives were found to be much less active than carvacrol.
合成了十四种百里香酚和香芹酚酯，并根据光谱数据对其进行了表征。其中一些化合物的核磁共振数据首次公布。对百里香酚、香芹酚及其酯类进行了抗菌活性筛选，测试对象为四种革兰氏阳性菌（变形链球菌MTCC 890、金黄色葡萄球菌MTCC 96、枯草芽孢杆菌MTCC 121、表皮葡萄球菌MTCC 435）和一种革兰氏阴性菌（大肠杆菌MTCC 723）。与百里香酚相比，发现百里香酚酯衍生物4a - c（对变形链球菌、枯草芽孢杆菌和表皮葡萄球菌）的活性增强，而香芹酚衍生物的活性比香芹酚低得多。
