Debarbieux S, Deroo-Berger M-C, Grande S, Najioullah F, Kanitakis J, Faure M, Claudy A
Service de Dermatologie, Pavillon R, Hôpital Edouard Herriot, Lyon.
Ann Dermatol Venereol. 2006 Feb;133(2):145-7. doi: 10.1016/s0151-9638(06)70865-1.
Drug hypersensitivity syndrome is a severe life-threatening drug reaction. An association between this syndrome and HHV6 reactivation has been hypothesized.
CASE-REPORT: A 45 year-old women was treated with sulfasalazine for polyarthralgia. One month after beginning the treatment, she developed a drug hypersensitivity syndrome with severe acute hepatic failure. HHV6 serology and serum PCR revealed a primary HHV6 infection.
We report the second case of drug hypersensitivity syndrome associated with a primary HHV6 infection. An immunological disorder may explain such an association by increasing viral replication. Detection and titration of anti-HHV6 antibodies in each case of drug hypersensitivity syndrome should help to confirm this association and possibly modify treatment strategy.
药物超敏反应综合征是一种严重的、危及生命的药物反应。该综合征与HHV6重新激活之间的关联已被提出假设。
一名45岁女性因多关节痛接受柳氮磺胺吡啶治疗。治疗开始一个月后，她出现了伴有严重急性肝衰竭的药物超敏反应综合征。HHV6血清学和血清PCR检测显示为原发性HHV6感染。
我们报告了第二例与原发性HHV6感染相关的药物超敏反应综合征病例。免疫紊乱可能通过增加病毒复制来解释这种关联。在每例药物超敏反应综合征中检测和滴定抗HHV6抗体应有助于证实这种关联，并可能改变治疗策略。
