Heinzelmann-Schwarz V A, Gardiner-Garden M, Henshall S M, Scurry J P, Scolyer R A, Smith A N, Bali A, Vanden Bergh P, Baron-Hay S, Scott C, Fink D, Hacker N F, Sutherland R L, O'Brien P M
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Br J Cancer. 2006 Mar 27;94(6):904-13. doi: 10.1038/sj.bjc.6603003.
Mucinous epithelial ovarian cancers (MOC) are clinically and morphologically distinct from the other histological subtypes of ovarian cancer. To determine the genetic basis of MOC and to identify potential tumour markers, gene expression profiling of 49 primary ovarian cancers of different histological subtypes was performed using a customised oligonucleotide microarray containing >59 000 probesets. The results show that MOC express a genetic profile that both differs and overlaps with other subtypes of epithelial ovarian cancer. Concordant with its histological phenotype, MOC express genes characteristic of mucinous carcinomas of varying epithelial origin, including intestinal carcinomas. Differences in gene expression between MOC and other histological subtypes of ovarian cancer were confirmed by RT-PCR and/or immunohistochemistry. In particular, galectin 4 (LGALS4) was highly and specifically expressed in MOC, but expressed at lower levels in benign mucinous cysts and borderline (atypical proliferative) tumours, supporting a malignant progression model of MOC. Hence LGALS4 may have application as an early and differential diagnostic marker of MOC.
黏液性上皮性卵巢癌（MOC）在临床和形态学上与卵巢癌的其他组织学亚型不同。为了确定MOC的遗传基础并识别潜在的肿瘤标志物，使用包含>59000个探针集的定制寡核苷酸微阵列对49例不同组织学亚型的原发性卵巢癌进行了基因表达谱分析。结果表明，MOC表达的基因谱与上皮性卵巢癌的其他亚型既有差异又有重叠。与其组织学表型一致，MOC表达不同上皮来源的黏液性癌的特征性基因，包括肠道癌。通过逆转录聚合酶链反应（RT-PCR）和/或免疫组织化学证实了MOC与卵巢癌其他组织学亚型之间的基因表达差异。特别是，半乳糖凝集素4（LGALS4）在MOC中高度特异性表达，但在良性黏液囊肿和交界性（非典型增生性）肿瘤中表达水平较低，支持MOC的恶性进展模型。因此，LGALS4可能作为MOC的早期和鉴别诊断标志物。
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