LeBlanc Gabrielle, Bell Sarah G, Delfyett William, Enloe Brian, Courtney-Brooks Madeleine, Boisen Michelle
Department of Obstetrics and Gynecology, University of Pittsburgh Medical Center, United States.
Department of Radiology, University of Pittsburgh Medical Center, United States.
Gynecol Oncol Rep. 2025 Apr 19;59:101749. doi: 10.1016/j.gore.2025.101749. eCollection 2025 Jun.
Ovarian cancer is the fifth most common cause of cancer death in women and represents the deadliest of the gynecologic cancers. Despite treatment, 80 % of patients diagnosed with ovarian cancer will experience recurrence of disease within 18 months. Mucinous ovarian carcinoma represents an exceptionally rare subtype of ovarian cancer, comprising only 1-3 % of cases. Roughly 65-80 % of cases are diagnosed early at FIGO stage I with an excellent prognosis. However, for those diagnosed with advanced stage III-IV primary or recurrent disease, prognosis is extremely poor secondary to aggressive tumor biology and poor response to traditional platinum-based chemotherapy. Ovarian cancer recurrence most commonly arises secondary to transperitoneal and lymphatic spread of neoplastic cells. Central nervous system seeding, particularly leptomeningeal metastasis, is exceptionally rare with only palliative treatment options. Here, we describe a 44-year-old female with leptomeningeal recurrence remote from surgical treatment of stage IA mucinous ovarian carcinoma.
卵巢癌是女性癌症死亡的第五大常见原因，也是最致命的妇科癌症。尽管进行了治疗，但80%被诊断为卵巢癌的患者会在18个月内出现疾病复发。黏液性卵巢癌是卵巢癌中一种极其罕见的亚型，仅占病例的1%-3%。大约65%-80%的病例在FIGO I期被早期诊断，预后良好。然而，对于那些被诊断为III-IV期原发性或复发性晚期疾病的患者，由于肿瘤生物学行为侵袭性强且对传统铂类化疗反应不佳，预后极差。卵巢癌复发最常见的原因是肿瘤细胞的经腹膜和淋巴转移。中枢神经系统播散，尤其是软脑膜转移，极为罕见，且只有姑息治疗方案。在此，我们描述了一名44岁女性，她患有距IA期黏液性卵巢癌手术治疗部位较远的软脑膜复发。
