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哪些服用选择性5-羟色胺再摄取抑制剂(SSRI)的患者出血风险最高?

Which patients taking SSRIs are at greatest risk of bleeding?

作者信息

Mansour Ahmed, Pearce Mark, Johnson Benjamin, Sey Michael Sai Lai, Oda Ninos, Collegala Natasha, Krishnadev Upasana, Bhalerao Shree

机构信息

St. Michael's Hospital, Medical Psychiatry Service, Toronto, Ontario M5B 1W8, Canada.

出版信息

J Fam Pract. 2006 Mar;55(3):206-8.

PMID:16510053
Abstract

For patients at high risk of abnormal bleeding, consider prescribing an antidepressant with low serotonin reuptake inhibition, which may lower risk. For patients taking high-serotonin reuptake inhibition antidepressants, recommend avoidance or minimal use of nonsteroidal anti-inflammatory drugs and aspirin.

摘要

对于有异常出血高风险的患者,考虑开具血清素再摄取抑制作用较低的抗抑郁药,这可能会降低风险。对于正在服用高血清素再摄取抑制作用抗抑郁药的患者,建议避免或尽量少用非甾体抗炎药和阿司匹林。

相似文献

1
Which patients taking SSRIs are at greatest risk of bleeding?哪些服用选择性5-羟色胺再摄取抑制剂(SSRI)的患者出血风险最高?
J Fam Pract. 2006 Mar;55(3):206-8.
2
[Is the use of selective serotonin reuptake inhibitors associated with an increased risk of bleeding?].[使用选择性5-羟色胺再摄取抑制剂是否与出血风险增加有关?]
Ugeskr Laeger. 2006 Jun 5;168(23):2232-6.
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Serotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanisms.5-羟色胺再摄取抑制剂类抗抑郁药与异常出血:临床医生的综述与作用机制再思考。
J Clin Psychiatry. 2010 Dec;71(12):1565-75. doi: 10.4088/JCP.09r05786blu.
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Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study.选择性5-羟色胺再摄取抑制剂的使用与上消化道出血风险:一项基于人群的队列研究。
Arch Intern Med. 2003 Jan 13;163(1):59-64. doi: 10.1001/archinte.163.1.59.
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Risk of upper gastrointestinal bleeding and the degree of serotonin reuptake inhibition by antidepressants: a case-control study.上消化道出血风险与抗抑郁药对5-羟色胺再摄取的抑制程度:一项病例对照研究。
Drug Saf. 2008;31(2):159-68. doi: 10.2165/00002018-200831020-00005.
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Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study.选择性5-羟色胺再摄取抑制剂与上消化道出血之间的关联:基于人群的病例对照研究。
BMJ. 1999 Oct 23;319(7217):1106-9. doi: 10.1136/bmj.319.7217.1106.
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Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding?选择性5-羟色胺再摄取抑制剂与非甾体抗炎药同时处方是否会大幅增加上消化道出血的风险?
Aliment Pharmacol Ther. 2005 Aug 1;22(3):175-81. doi: 10.1111/j.1365-2036.2005.02543.x.
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Contribution of Helicobacter pylori infection to the risk of peptic ulcer bleeding in patients on nonsteroidal anti-inflammatory drugs, antiplatelet agents, anticoagulants, corticosteroids and selective serotonin reuptake inhibitors.幽门螺杆菌感染对服用非甾体抗炎药、抗血小板药物、抗凝剂、皮质类固醇和选择性 5-羟色胺再摄取抑制剂的患者发生消化性溃疡出血的风险的影响。
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Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis.选择性 5-羟色胺再摄取抑制剂联合或不联合非甾体抗炎药使用时上消化道出血的风险:系统评价和荟萃分析。
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Association between SSRIs and upper gastrointestinal bleeding. Self treatment with non-steroidal drugs may be confounding factor.选择性5-羟色胺再摄取抑制剂(SSRIs)与上消化道出血之间的关联。使用非甾体类药物进行自我治疗可能是一个混杂因素。
BMJ. 2000 May 20;320(7246):1406.

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Antidepressants and the risk of abnormal bleeding during spinal surgery: a case–control study.抗抑郁药与脊柱手术期间异常出血风险:病例对照研究。
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