Ambalavanar Ranjinidevi, Moutanni Aicha, Dessem Dean
Department of Biomedical Sciences, University of Maryland, Rm 4E-02, 666 West Baltimore Street, Baltimore, MD 21201, USA.
Neurosci Lett. 2006 May 22;399(3):249-54. doi: 10.1016/j.neulet.2006.02.003. Epub 2006 Feb 28.
The modulation of behavioral responses evoked by local and distant nociceptive stimuli following a discrete somatic injection of complete Freund's adjuvant (CFA) was examined in rats. Inflammation of one craniofacial muscle evoked mechanical allodynia not only in the region of inflammation but also secondary mechanical allodynia in the contralateral head, ipsilateral hindpaw, and contralateral hindpaw. In contrast to this, CFA-induced inflammation of either the hindpaw or gastrocnemius muscle evoked mechanical allodynia restricted to the hindlimb region. The widespread modulation of nocifensive behavior evoked by inflammation of deep craniofacial tissue found in this study resembles the widespread deep tissue pain reported in fibromyalgia, whiplash injury and some temporomandibular disorders and thus may provide insight into the mechanisms of these musculoskeletal pathologies.
在大鼠中，研究了在离散躯体注射完全弗氏佐剂（CFA）后，局部和远处伤害性刺激诱发的行为反应的调制情况。一侧颅面部肌肉的炎症不仅在炎症区域诱发机械性异常性疼痛，还在对侧头部、同侧后爪和对侧后爪诱发继发性机械性异常性疼痛。与此相反，CFA诱导的后爪或腓肠肌炎症诱发的机械性异常性疼痛局限于后肢区域。本研究中发现的深部颅面部组织炎症诱发的伤害防御行为的广泛调制，类似于纤维肌痛、挥鞭样损伤和一些颞下颌关节紊乱症中报道的广泛深部组织疼痛，因此可能为这些肌肉骨骼疾病的机制提供见解。
