Arao Y, Hatano A, Yamada M, Uno F, Nii S
Department of Virology, Okayama University Medical School, Japan.
Acta Med Okayama. 1991 Apr;45(2):117-21. doi: 10.18926/AMO/32190.
Ability of two neurovirulent strains (F and +GC (LPV) Miyama) of herpes simplex virus type 1 (HSV-1) to establish and maintain reactivatable latency in trigeminal ganglia (TG) was compared after intranasal inoculation of mice. The +GC (LPV) Miyama strain showed a very low rate of virus reactivation in explant cultures of TG, while the F strain showed a high rate of reactivation. These data indicate that neurovirulent strains of HSV-1 are not always competent for reactivatable latency, although most virulent strains of HSV-1 thus far reported were competent for reactivatable latency.
在对小鼠进行鼻内接种后，比较了1型单纯疱疹病毒（HSV-1）的两种神经毒力株（F株和+GC（LPV）宫山株）在三叉神经节（TG）中建立和维持可再激活潜伏状态的能力。+GC（LPV）宫山株在TG的外植体培养物中显示出非常低的病毒再激活率，而F株显示出高再激活率。这些数据表明，HSV-1的神经毒力株并不总是能够实现可再激活潜伏状态，尽管迄今为止报道的大多数HSV-1强毒株都能够实现可再激活潜伏状态。
