抗心磷脂抗体的持续存在与狼疮抗凝物及抗β2糖蛋白I抗体出现的风险增加相关。
The persistence of anticardiolipin antibodies is associated with an increased risk of the presence of lupus anticoagulant and anti-beta2-glycoprotein I antibodies.
作者信息
Neville C, Rauch J, Kassis J, Solymoss S, Joseph L, Belisle P, Subang R, Chang E R, Fortin P R
机构信息
Division of Clinical Epidemiology, Montreal General Hospital, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
出版信息
Rheumatology (Oxford). 2006 Sep;45(9):1116-20. doi: 10.1093/rheumatology/kel050. Epub 2006 Mar 1.
OBJECTIVE
We studied antiphospholipid antibodies (aPL) in blood samples from a cohort of individuals followed for thrombosis to determine whether the persistent presence of anticardiolipin antibodies (aCL) is associated with a greater likelihood of having lupus anticoagulant and/or anti-beta2-glycoprotein I antibodies (LA/abeta2GPI).
METHODS
Blood samples from 353 individuals who had been tested for aCL on at least two occasions were tested for abeta2GPI and LA. Two groups were defined: aCL-persistent, who tested aCL-positive on at least two occasions, and aCL non-persistent, who tested aCL-positive on fewer than two occasions. Multivariate logistic regressions were performed using LA/abeta2GPI, LA and abeta2GPI as outcome variables and the percentage of aCL-positive tests as the predictor variable, adjusted for age, gender, family history of cardiovascular disease (CVD), systemic lupus erythematosus (SLE), smoking and number of venous (VT) and arterial thromboses (AT).
RESULTS
Sixty-eight (19%) individuals were aCL persistent and 285 (81%) were aCL non-persistent. LA/abeta2GPI was found in 36 (53%) of the aCL persistent group and 38 (13%) of the aCL non-persistent group. The two groups were similar for age, gender and smoking. Family history of CVD, SLE, VT and AT were more frequent in the aCL persistent group. Multivariate analyses revealed that odds ratios for LA/abeta2GPI, LA and abeta2GPI were 1.34 [95% confidence interval (CI) = 1.22-1.47], 1.36 (95% CI = 1.24-1.50) and 1.47 (95% CI = 1.31-1.65) respectively for each 10% increase in aCL-positive tests vs 0% positive tests.
CONCLUSION
Persistence of aCL positivity is associated with an increased risk of LA/abeta2GPI.
目的
我们对一组因血栓形成而接受随访的个体的血样进行抗磷脂抗体（aPL）研究，以确定抗心磷脂抗体（aCL）的持续存在是否与狼疮抗凝物和/或抗β2糖蛋白I抗体（LA/抗β2GPI）的出现可能性增加相关。
方法
对353名至少接受过两次aCL检测的个体的血样进行抗β2GPI和LA检测。定义了两组：aCL持续阳性组，即至少两次检测aCL呈阳性；aCL非持续阳性组，即检测aCL呈阳性的次数少于两次。以LA/抗β2GPI、LA和抗β2GPI作为结果变量，aCL阳性检测的百分比作为预测变量进行多因素逻辑回归分析，并对年龄、性别、心血管疾病（CVD）家族史、系统性红斑狼疮（SLE）、吸烟以及静脉血栓形成（VT）和动脉血栓形成（AT）的数量进行校正。
结果
68名（19%）个体aCL持续阳性，285名（81%）个体aCL非持续阳性。aCL持续阳性组中36名（53%）检测出LA/抗β2GPI，aCL非持续阳性组中38名（13%）检测出LA/抗β2GPI。两组在年龄、性别和吸烟方面相似。CVD家族史、SLE、VT和AT在aCL持续阳性组中更为常见。多因素分析显示，aCL阳性检测每增加10%（相对于0%阳性检测），LA/抗β2GPI、LA和抗β2GPI的比值比分别为1.34[95%置信区间（CI）=1.22 - 1.47]、1.36（95%CI = 1.24 - 1.50）和1.47（95%CI = 1.31 - 1.65）。
结论
aCL阳性的持续存在与LA/抗β2GPI风险增加相关。
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