Puro D G
Department of Ophthalmology, University of Michigan School of Medicine, Ann Arbor 48105.
Brain Res. 1991 May 10;548(1-2):329-33. doi: 10.1016/0006-8993(91)91143-o.
A calcium-permeable, voltage-insensitive non-specific cation channel that is activated by cytoplasmic calcium was found in approximately 50% of the cell-attached patches in cultured human retinal glial cells sampled by the patch clamp technique. Spontaneous openings of this channel were infrequent, but increased markedly when glial cells were exposed to basic fibroblast growth factor. Although the role of these cation channels is uncertain, they provide a mechanism to perpetuate a transient rise in cytosolic calcium induced by the release of calcium from intracellular stores.
通过膜片钳技术对培养的人视网膜神经胶质细胞进行采样时，在大约50%的细胞贴附膜片中发现了一种钙通透性、电压不敏感的非特异性阳离子通道，该通道由细胞质钙激活。这种通道的自发开放很少见，但当神经胶质细胞暴露于碱性成纤维细胞生长因子时，开放明显增加。尽管这些阳离子通道的作用尚不确定，但它们提供了一种机制，使细胞内钙库释放钙所诱导的细胞质钙的短暂升高得以持续。
