通过针刺穴位暴露于偏振光来抑制疼痛。
Suppression of pain by exposure of acupuncture points to polarized light.
作者信息
Limansky Yuri P, Tamarova Zinaida A, Gulyar Sergiy A
机构信息
Bogomoletz Institute of Physiology, National Academy of Sciences, Kiev, Ukraine. liman@
出版信息
Pain Res Manag. 2006 Spring;11(1):49-57. doi: 10.1155/2006/784968.
BACKGROUND
According to clinical studies, the stimulation of acupuncture points (APs) by a variety of methods (eg, needles, pressure, etc) is an effective method for the treatment of many pain syndromes. However, no experimental proof exists showing that the exposure of APs to low-intensity incoherent polarized (P) light evokes an analgesic affect.
OBJECTIVES
The authors' previous work, using mice, shows that the exposure of APs to low-intensity microwaves effectively decreases pain. The purpose of the present study was to determine whether exposure of APs to low-intensity incoherent P light evokes a statistically significant reduction in pain.
METHODS
The effects of P light on behavioural responses to acute and tonic pain were tested in mice. The threshold of vocalization during electrical stimulation of the foot (acute pain) was measured before and after exposure of AP E-36 to P light. The duration of licking the formalin-injected foot (tonic pain) was investigated in control mice and mice exposed to P light on APs E-36, V-56 and V-60 or on skin that did not contain analgesic APs.
RESULTS
Exposure of APs to P light evoked a statistically significant increase in pain threshold by 34.2% to 59.1%, and shortened the licking time by 32.3% to 50% in mice. The most effective AP was E-36 in both the painful foot and the normal foot. After 2 min, 6 min and 10 min of P light exposure, analgesia was 7.6%, 30.9% and 50%, respectively. The exposure to P light on skin that did not contain analgesic APs did not evoke significant effect.
CONCLUSIONS
The results show the efficacy of pain suppression by exposure of antinociceptive APs to P light.
背景
根据临床研究，通过多种方法（如针刺、按压等）刺激穴位是治疗多种疼痛综合征的有效方法。然而，尚无实验证据表明穴位暴露于低强度非相干偏振（P）光会产生镇痛作用。
目的
作者之前使用小鼠进行的研究表明，穴位暴露于低强度微波可有效减轻疼痛。本研究的目的是确定穴位暴露于低强度非相干P光是否能在统计学上显著减轻疼痛。
方法
在小鼠中测试P光对急性和持续性疼痛行为反应的影响。在穴位E-36暴露于P光之前和之后，测量电刺激足部时的发声阈值（急性疼痛）。在对照小鼠以及穴位E-36、V-56和V-60或不含镇痛穴位的皮肤上暴露于P光的小鼠中，研究舔舐注射福尔马林的足部的持续时间（持续性疼痛）。
结果
穴位暴露于P光使小鼠的疼痛阈值在统计学上显著提高34.2%至59.1%，并使舔舐时间缩短32.3%至50%。在疼痛足部和正常足部，最有效的穴位都是E-36。在暴露于P光2分钟、6分钟和10分钟后，镇痛效果分别为7.6%、30.9%和50%。在不含镇痛穴位的皮肤上暴露于P光未产生显著效果。
结论
结果表明，抗伤害感受性穴位暴露于P光可有效抑制疼痛。
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