信号受体结构域的物理化学性质作为序列比较的基础。
Physicochemical properties of signal receptor domains as the basis for sequence comparison.
作者信息
Berman A L, Dityatev A E, Frishman D I
机构信息
Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences, Leningrad, USSR.
出版信息
Comp Biochem Physiol B. 1991;98(4):445-9. doi: 10.1016/0305-0491(91)90238-9.
PMID:1651202
Abstract
- An algorithm of sequence comparison based on average bulkiness of amino acids in protein domains and not requiring sequence alignment is described. 2. A complete evolutionary tree of the signal receptor proteins is built. The STE2 proteins are shown to belong to this family. 3. Factorial analysis of average bulkiness makes it possible to discriminate functional and intraspecies differences between proteins.
摘要
- 描述了一种基于蛋白质结构域中氨基酸平均疏水性且无需序列比对的序列比较算法。2. 构建了信号受体蛋白的完整进化树。结果表明STE2蛋白属于该家族。3. 对平均疏水性进行因子分析能够区分蛋白质之间的功能差异和种内差异。
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