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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

al-Zamil Z, Bagust J, Kerkut G A

Department of Neurophysiology, The Medical School, Southampton University, England.

Gen Pharmacol. 1991;22(3):559-65. doi: 10.1016/0306-3623(91)90024-z.

In the lumbar spinal cord, 10(-6) M bicuculline reduces the inhibition of the dorsal root-ventral root (DR-VR) reflex produced by lateral stimulation of the spinal cord. The inhibition returns on washing in control artificial cerebrospinal fluid (ACSF). 2. Baclofen (10(-6) M) inhibits the monosynaptic DR-VR reflex which returns on washing in control ACSF. 3. This suggests an involvement of GABAA receptors in the lateral inhibition and GABAB receptors in the DR-VR reflex system. 4. The increased activity seen following bicuculline or tubocurarine probably resets the "set point" of neural activity to a lower level.

在腰段脊髓中，10⁻⁶ M荷包牡丹碱可减少脊髓外侧刺激所产生的背根 - 腹根（DR - VR）反射的抑制作用。在换用对照人工脑脊液（ACSF）冲洗后，抑制作用恢复。2. 巴氯芬（10⁻⁶ M）可抑制单突触DR - VR反射，在换用对照ACSF冲洗后该反射恢复。3. 这表明GABAA受体参与了外侧抑制作用，而GABAB受体参与了DR - VR反射系统。4. 荷包牡丹碱或筒箭毒碱处理后所观察到的活动增加可能将神经活动的“设定点”重置为较低水平。

al-Zamil Z, Bagust J, Kerkut G A

Department of Neurophysiology, The Medical School, Southampton University, England.

Gen Pharmacol. 1991;22(3):559-65. doi: 10.1016/0306-3623(91)90024-z.

In the lumbar spinal cord, 10(-6) M bicuculline reduces the inhibition of the dorsal root-ventral root (DR-VR) reflex produced by lateral stimulation of the spinal cord. The inhibition returns on washing in control artificial cerebrospinal fluid (ACSF). 2. Baclofen (10(-6) M) inhibits the monosynaptic DR-VR reflex which returns on washing in control ACSF. 3. This suggests an involvement of GABAA receptors in the lateral inhibition and GABAB receptors in the DR-VR reflex system. 4. The increased activity seen following bicuculline or tubocurarine probably resets the "set point" of neural activity to a lower level.

在腰段脊髓中，10⁻⁶ M荷包牡丹碱可减少脊髓外侧刺激所产生的背根 - 腹根（DR - VR）反射的抑制作用。在换用对照人工脑脊液（ACSF）冲洗后，抑制作用恢复。2. 巴氯芬（10⁻⁶ M）可抑制单突触DR - VR反射，在换用对照ACSF冲洗后该反射恢复。3. 这表明GABAA受体参与了外侧抑制作用，而GABAB受体参与了DR - VR反射系统。4. 荷包牡丹碱或筒箭毒碱处理后所观察到的活动增加可能将神经活动的“设定点”重置为较低水平。