他莫昔芬联合顺铂对口腔鳞状细胞癌细胞系的作用。
The role of tamoxifen in combination with cisplatin on oral squamous cell carcinoma cell lines.
作者信息
Kim Myung-Jin, Lee Jong-Ho, Kim Young-Kyun, Myoung Hoon, Yun Pil-Young
机构信息
Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University, South Korea.
出版信息
Cancer Lett. 2007 Jan 8;245(1-2):284-92. doi: 10.1016/j.canlet.2006.01.017. Epub 2006 Mar 2.
The purpose of this study was to evaluate the effect of tamoxifen (TAM) when used in combination with cisplatin on oral squamous cell carcinoma (OSCC). For this, the relation between estrogen receptor (ER) expression level and the cytotoxic effect of TAM, the apoptotic effect and its molecular mechanisms of TAM were investigated using OSCC cell lines. Combination treatment demonstrated a superior cytotoxic and apoptotic effect on OSCC cell lines. Considerable amount of ER was detected in some OSCC cell lines, but there were no significant differences of cytotoxic effect of TAM. TAM inhibited PKC activity and up-regulated TGF-beta1 secretion.
本研究的目的是评估他莫昔芬（TAM）与顺铂联合使用对口腔鳞状细胞癌（OSCC）的影响。为此，使用OSCC细胞系研究了雌激素受体（ER）表达水平与TAM细胞毒性作用之间的关系、TAM的凋亡作用及其分子机制。联合治疗对OSCC细胞系显示出更强的细胞毒性和凋亡作用。在一些OSCC细胞系中检测到大量ER，但TAM的细胞毒性作用没有显著差异。TAM抑制PKC活性并上调TGF-β1分泌。
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