Grimm M, Biegner T, Teriete P, Hoefert S, Krimmel M, Munz A, Reinert S
Department of Oral and Maxillofacial Surgery, University Hospital Tuebingen, Osianderstrasse 2-8, 72076, Tuebingen, Germany,
Med Oral Patol Oral Cir Bucal. 2016 Sep 1;21(5):e554-8. doi: 10.4317/medoral.21182.
Recent studies have shown an increase in the incidence of oral squamous cell carcinoma (OSCC) in younger patients. The hypothesis that tumors could be hormonally induced during pregnancy or in young female patients without the well-known risk factors alcohol or tobacco abuse seems to be plausible.
Estrogen Receptor alpha (ERα) and Progesterone Receptor (PR) expression were analyzed in normal oral mucosa (n=5), oral precursor lesions (simple hyperplasia, n=11; squamous intraepithelial neoplasia, SIN I-III, n=35), and OSCC specimen. OSCCs were stratified in a young female (n=7) study cohort and older patients (n=46). In the young female study cohort three patients (n=3/7) developed OSCC during or shortly after pregnancy. Breast cancer tissues were used as positive control for ERα and PR expression.
ERα expression was found in four oral precursor lesions (squamous intraepithelial neoplasia, SIN I-III, n=4/35, 11%) and in five OSCC specimen (n=5/46, 11%). The five ERα positive OSCC samples were older male patients. All patients within the young female study cohort were negatively stained for both ERα and PR.
ER expression could be regarded as a seldom risk factor for OSCC. PR expression seems to be not relevant for the development of OSCC.
最近的研究表明，年轻患者口腔鳞状细胞癌（OSCC）的发病率有所上升。肿瘤可能在怀孕期间或年轻女性患者中由激素诱导产生，而这些患者没有众所周知的危险因素，如酗酒或吸烟，这一假设似乎是合理的。
分析雌激素受体α（ERα）和孕激素受体（PR）在正常口腔黏膜（n = 5）、口腔前驱病变（单纯增生，n = 11；鳞状上皮内瘤变，SIN I - III，n = 35）和OSCC标本中的表达。OSCC患者被分为年轻女性研究队列（n = 7）和老年患者队列（n = 46）。在年轻女性研究队列中，有3名患者（n = 3/7）在怀孕期间或产后不久发生了OSCC。乳腺癌组织用作ERα和PR表达的阳性对照。
在4例口腔前驱病变（鳞状上皮内瘤变，SIN I - III，n = 4/35，11%）和5例OSCC标本（n = 5/46，11%）中发现了ERα表达。5例ERα阳性的OSCC样本均为老年男性患者。年轻女性研究队列中的所有患者ERα和PR染色均为阴性。
ER表达可被视为OSCC的一个罕见危险因素。PR表达似乎与OSCC的发生无关。
