Condat Bertrand, Zanditenas David, Collot Véronique, Legoupil Nathalie, Cazals-Hatem Dominique, Hauuy Marie-Pierre, Bonnet Joëlle, Ngo Yann, Roucoules Jacques, Blazquez Martine
Services d'Hépato-Gastroentérologie, Hôpital Saint-Camille, Bry-sur-Marne.
Gastroenterol Clin Biol. 2006 Jan;30(1):142-6. doi: 10.1016/s0399-8320(06)73131-1.
The DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) corresponds to a drug reaction generally including cutaneous eruption, fever, hematologic abnormalities such as eosinophilia and atypical lymphocytosis and one or more specific visceral lesions specially in the liver. We report a case of drug hypersensitivity syndrome or DRESS associated with intra and extra-hepatic biliary lesions. This syndrome was associated with sulfasalazine and naproxene therapy. A reactivation of HHV6 was documented in the continuations of the DRESS and could play a role in the symptomms.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）对应一种药物反应，通常包括皮疹、发热、血液学异常如嗜酸性粒细胞增多和非典型淋巴细胞增多，以及一个或多个特定的内脏损害，特别是肝脏损害。我们报告一例与肝内和肝外胆管病变相关的药物超敏综合征或DRESS。该综合征与柳氮磺胺吡啶和萘普生治疗有关。在DRESS病程中记录到人类疱疹病毒6型（HHV6）再激活，其可能在症状中起作用。
