Tangjitgamol S, Manusirivithaya S, Leelahakorn S, Thawaramara T, Suekwatana P, Sheanakul C
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, Thailand.
Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:384-90. doi: 10.1111/j.1525-1438.2006.00492.x.
We present the case of a 5-year-old girl with ovarian immature teratoma, which recurred a few months after an incomplete surgical staging. The recurrent masses, located in the upper abdomen and lower pelvis, were accompanied by rise in levels of serum alpha-fetoprotein. The patient and her parents refused surgical resection of these recurrent masses; therefore, chemotherapy was promptly given. After multiple cycles of chemotherapy, all the masses remained stable in size despite normalization of the tumor marker. Subsequent complete resection of the masses showed only mature teratoma (MT) component without any residual malignant germ cell tumor. The patient was disease free for 2 years, when another episode of recurrence developed as a 5-cm mass in the perihepatic area. The third laparotomy revealed a tumor mass, histologically composed of only MT tissue. She is now doing well without any evidence of the disease, 24 months after the last surgery.
我们报告一例5岁患有卵巢未成熟畸胎瘤的女孩，其在不完全手术分期后数月复发。复发肿块位于上腹部和下盆腔，伴有血清甲胎蛋白水平升高。患者及其父母拒绝手术切除这些复发肿块；因此，立即给予化疗。经过多个周期的化疗，尽管肿瘤标志物恢复正常，但所有肿块大小保持稳定。随后对肿块进行的完整切除显示仅为成熟畸胎瘤（MT）成分，无任何残留恶性生殖细胞肿瘤。患者无病生存2年，之后在肝周区域出现一个5厘米的肿块，再次复发。第三次剖腹探查发现一个肿瘤肿块，组织学检查仅由MT组织构成。自上次手术后24个月，她目前情况良好，无任何疾病迹象。
