儿童急性淋巴细胞白血病的治疗史：癌症治愈的范例

History of the treatment of childhood ALL: a paradigm for cancer cure.

作者信息

Simone Joseph V

机构信息

University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, USA.

出版信息

Best Pract Res Clin Haematol. 2006;19(2):353-9. doi: 10.1016/j.beha.2005.11.003.

DOI:10.1016/j.beha.2005.11.003

PMID:16516133

Abstract

The history of the treatment of childhood leukemia from 1950 to the present is reviewed here. Particular emphasis is placed on the 'Total Therapy' studies conducted at St Jude Children's Research Hospital in Memphis, Tennessee. Under the guidance of Donald Pinkel, MD, the first medical director of St Jude, variations in chemotherapy and craniospinal irradiation were tried, and by Study XV, begun in 2000, a 4-year event-free survival of 92+/-7% had been achieved. Strengths and weaknesses in the current treatment of childhood leukemia are discussed as well as possibilities for the future.

摘要

本文回顾了1950年至今儿童白血病的治疗历史。特别强调了田纳西州孟菲斯市圣裘德儿童研究医院开展的“全疗法”研究。在圣裘德首任医学主任唐纳德·平克尔医生的指导下，尝试了化疗和颅脑脊髓放疗的不同方案，到2000年开始的第十五项研究时，已实现了92±7%的4年无事件生存率。文中还讨论了当前儿童白血病治疗的优缺点以及未来的可能性。